(a) A yeast-fly conserved pathway map. Pathways from yeast were used to query the fly network. nodes represent best-match pathways and are connected if they share more than two proteins. nodes are colored according to their predicted function based on the yeast query proteins. Best-match pathways in which significantly many proteins are annotated with the predicted function appear as boxes.

(a) (b)

(b) A querying example. QPath was applied to query the human MAPK pathway (red nodes) within the fly network (blue nodes). The best scoring pathway (dark blue nodes) contains two insertions relative to the query. Fly proteins that are similar to the query are shown in light green. Adapted from Shlomi et al. 33